The diagnostic and therapeutic potential of exosomal proteins in breast cancer

Exosomes are membrane vesicles 30–150 nm in size released by cells upon fusion of multivesicular bodies with the plasma membrane. A distinctive feature these is presence surface tetraspanins CD9, CD63, and CD81. The Rab family small GTPases, including Rab27A Rab27B, controls various steps exosome release, transport body to It commonly accepted date that exosomes main carriers information between under physiological conditions, such as mammary development lactation, pathological breast cancer. This review considers peculiarities formation, secretion transport, their composition role normal cancer, well prospects for using develop early non-invasive diagnostics improve effectiveness anti-tumor therapy.